Scientific Evidence for Adipose Derived Stem Cell Treatment of Musculoskeletal Diseases

Conveniently located to serve the areas of Los Angeles

Degenerative Joint Osteoarthritis

  1. Michalek J, Moster R, Lukac L, et al. Autologous adipose tissue-derived stromal vascular fraction cells application in patients with osteoarthritis. Cell transplantation (currently in press).
  2. Nguyen PD, Tran TD, Nguyen HT, Vu HT, Le PT, Phan NL, Vu NB, Phan NK, Van Pham P. Comparative clinical observation of arthroscopic microfracture in the presence and absence of stromal vascular fraction injection for osteoarthritis. Stem Cell And Translational Medicine 2017 Jan; 6( 1): 187-195.
  3. Pers YM, Rackwitz L, Ferreira R, Pulliq 0, Delfour C, Barry F, Sensebe L, Casteilia L, Fleury S, Bourin P, Noel D, Canovas F, Cyteval C, Lisiqnoli G, Schrauth J, Pladdad D, Domerque S, Noeth U, Jorgensen C; ADIPOA Consortium. Adipose mesenchymal stromal cell-based therapy for severe arthritis of the knee: a phase I dose escalation trial. Stem Cell Translational Medicine 2016 Jul; 5(7): 847-56.
  4. Fodor PB, Paulseth SG. Adipose derived stromal cell (ADSC) injections for pain management of osteoarthritis in the human knee joint. Anesthetic Surgical Journal 2016, Feb; 36(2): 229-36.
  5. Jaewoo Pak, Juno Hun Lee, Wiwi Andralia Kartolo, Sana Hee Lee. Cartilage regeneration in human with adipose tissue derived stem cells; current status and clinical implications. Biomedical Research International 2016 Jan. 6.
  6. Koh Y, Choi Y, Kwon S, Kim Y, Yeo J. Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy 2015.
  7. Kim Y, Choi Y, Suh D, et al. Mesenchymal stem cell implantation in osteoarthritic knees: is fibrin glue effective as a scaffold? The American Journal of Sports Medicine 2015; 43(1): 176-185.
  8. Bui K, Duong T, Nguyen N, et al. Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet rich plasma: a clinical study. Biomedical Research And Therapy 2014; 1(1) : 2-8.
  9. Pak J, Lee JH, Lee SH. Regenerative repair of damaged meniscus with autologous adipose tissue-derived stem cells. Biomedical Research International 2014; 2014: 10.
  10. Koh Y, Choi Y, Kwon S, Kim Y. Second look arthroscopic evaluation of cartilage lesions after mesenchymal stem cell implantation in osteoarthritic knees. American Journal of Sports Medicine 2014; 42(7): 1628-1637.
  11. Jo C, Lee Y, et al. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof of concept clinical trial. Stem Cells 2014; 32(5): 1254-1266.
  12. Koh Y, Jo S, Kwon O, et al. Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy 2013; 29(4): 748-755.
  13. Pak J, Chang J, Lee J, Lee S. Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet rich plasma into human articular joints. BMC Musculoskeletal Disorders 2013: 14 article 337.
  14. Koh Y, Choi Y. Infra patellar fat pad derived mesenchymal stem cell therapy for knee osteoarthritis. Knee 2012.04.0001.
  15. Pak J. Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose tissue-derived stem cells: a case series. Journal of Medical Case Reports 2011: 7 (5 article 296).
  16. Frisbie D, Kisiday J, Kawcak C, et al. Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis. Journal of Orthopaedic Research 2009; 27(12): 1675-1680.
  17. Centeno C, Busse D, Kisiday J, et al. Increase knee cartilage volume in degenerative joint disease using percutaneously implanted autologous mesenchymal stem cells. Pain Physician 2008; 11(3): 343-353.
  18. Draggo J, Carlson G, McCormick F, et al. Healing full thickness cartilage defects using adipose-derived stem cells. Tissue Engineering 2007; 36(7): 1615-1621.

Degenerative Disc Disease of the Spine

  1. Comella Kristin, Silbert Robert, Parlo Michelle. Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease. Journal of Translational Medicine 2017, Jan 13.
  2. Tuakli-Wosornu YA, Terry A, Boachie-Adjei I, Harrison JR, Gribbin CK, LaSaiie EE, Nguyen JT, Soiomon JL, Lutz GE. Lumbar intradiscal platelet rich plasma (PRP) injections: a prospective, double-blind, randomized controlled study. PMNR 2016 Jan; 8(1): 1-10.
  3. Gianluca Vadala, Fabrizio Russo, Luca Ambrosio, Mattia Loppini, Vincenzo Denar. Stem cells sources for intervertebral disc regeneration. World J Stem Cells. 2016 May 26; 8(5): 185-201.
  4. Hvowon Choi, Zariel I. Johnson , Makarand V. Risbud. Understanding nucleus pulposus cell phenotype: A prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Curr Stem Ceil Res Ther. 2015: 10(4): 307-316.
  5. Kenneth Pettine, Richard Suzuki, Theodore Sand, Matthew Murphy. Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up. International Orthopedics 2015 April.
  6. Song K, Gu T, Shuanq F, Tang J, Ren D, Qin J, Hou S. Adipose-derived stem cells improve the viability of nucleus pulposus cells in degenerated intervertebral discs. Mol Med Rep. 2015 Sep; 12(3): 4664-8.
  7. Krock E, Rosenzweiq DH, Haqlund L. The Inflammatory Milieu of the Degenerate Disc: Is Mesenchymal Stem Cell-based Therapy for Intervertebral Disc Repair a Feasible Approach? Curr Stem Cell Res Ther 2015; 10(4): 317-28.
  8. Wang F, Shi R, Cai F, Wang YT, Wu XT. Stem cell approaches to intervertebral disc degeneration: obstacles from the disc microenvironment stem cells. DEV 2015 Nov 1: 24(21): 2479-95.
  9. Ma CJ, Liu X, Che L, Liu ZH, Samartzis D, Wang HQ. Stem cell therapies for intervertebral disc degeneration: immune privilege reinforcement by FAS/FASL regulating machinery. Current Stem Cell Research Therapy 2015; 10(4): 285-95.
  10. Huang YC, Leung VY, Lu WW, Luk KD. The effects of microenvironment in mesenchymal stem cell-based regeneration of intervertebral disc. Spine J 2013 Mar; 13(3): 352-62.
  11. Huang S, Tam V, Cheung KM, Long D, Lv M, Wang T, Zhou G. Stem cell-based approaches for intervertebral disc degeneration. Current Stem Cell Research Therapy 2011 Dec; 6(4): 317-26.
  12. Orozco L, Soler R, Morera C, et at. Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study. Transplantation 2011; 92: 822-828.
  13. English K. Intervertebral disc repair: mesenchymal stem cells to the rescue? Transplantation 2011; 92: 733-734.
  14. Hiyama A, Mochida J, Iwashina T, et al. Transplantation of mesenchymal stem cells in the canine disc degeneration model. Journal Orthopedic Research 2008; 26: 589-600.
  15. Victor YL, Danny Chan, Kenneth Chong. Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction. Eur Sp J 2006 August.
  16. Richardson SM, Walker RV, Parker S, et all. Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 2006; 24: 707-716.
  17. Sakai D, Mochida J, Iwashina T, et al. Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential limitations for stem cell therapy in disc degeneration. Spine 2005; 30: 2379-2387.
  18. Steck E, Bertram H, Abel R, et al. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 2005; 23: 403-411.