Allogeneic Stem Cell Transplantation

Conveniently located to serve the areas of Los Angeles

Stem cells therapy utilizes cells which are derived from a variety of sources. Stem cell can be either harvested from the patient’s own body, or can be taken from other sources, which is called Allogeneic Stem Cells. The source of these external stem cells is from birth tissue, such as Wharton’s Jelly from the umbilical cord, placenta, cord blood, and amniotic fluid.

Why not use stem cells which are derived from your own body?

There are many individuals whose own stem cells are not optimal for use in stem cell therapy, either because of disease or active immunosuppressive treatment. These include people who have autoimmune disease, or have sustained environmental stressors or exposure, take multiple medications or chemotherapy; or even those who have poor quality stem cells from old age, diabetes, or other diseases. In these group of people Allogeneic Stem Cells is the optimal source for stem cell therapy.

Where do we obtain Allogeneic Stem Cell?

For patients with poorly functioning stem cells, our practice at the Stem Cell Institute of Los Angeles offers Allogeneic Stem Cell Transplantation utilizing Wharton’s Jelly Mesenchymal Stem Cells (MSCs) which are derived from the umbilical cord of healthy mothers having normal, full-term scheduled C-section deliveries. During the third trimester, the pregnant donors undergo extensive testing under strict government guidelines at FDA-regulated laboratories. These test include, but are not limited to:

  • 1. HBsAg (hepatitis B surface antigen).
  • 2. HBcAb (hepatitis B core antigen).
  • 3. HCV (hepatitis C antibody).
  • 4. HIV I/II-Ab (antibody to human immunodeficiency viruses type I and II).
  • 5. HIV NAT (HIV nucleic acid test), and HCV NAT (HCV nucleic acid test).
  • 6. Syphilis detection test.

Additionally, the tissue is tested post-processing to demonstrate the absence of bacterial and fungal pathogens and that the tissue is without fever-causing contaminants.

What is Wharton’s Jelly?

The umbilical cord connects the fetus to the placenta during pregnancy and contains umbilical vessels which are embedded within a mucous proteoglycan rich matrix. Wharton’s jelly is a gelatinous tissue within the center of the umbilical cord that contains mesenchymal stem cells (MSCs).

Large numbers of MSCs can be isolated from the Wharton’s jelly with minimal manipulation, without the need for culture, and contain large numbers of fresh live stem cells. These MSC properties are robustly expressed and functional, which are more comparable to fetal than adult stem cells.

Published medical studies indicate that MSCs harvested from the “young” Wharton’s jelly are considered more proliferative, immunosuppressive, and possibly therapeutically more active than stem cells isolated from older adult tissues. Additionally, Wharton's jelly mesenchymal stem cells are at such an early embryonic state which retain telomere length and protect them from premature loss of viability.

What are the Advantages of using Wharton’s Jelly?

  • Wharton’s jelly has a much higher concentration of Hyaluronic acid, cytokines and growth factors when compared to Amniotic Fluid.
  • May promote increased healing and enhancement of the wound healing process.
  • Non-immunogenic and has anti-apoptotic effects on muscle tissue.
  • May reduce pain at the site of application. May provide a natural biological barrier